Now it's two months out and it's two months back, when you're pushing the speed of light
Twenty years on your homeworld's track, pushing the speed of light
And your friends are gone and your lovers too
And there's damn-all left that you can do
And you try to lie, but you know it's true, pushing the speed of light
Pushing the speed of light
This reminds me of the final battle in the anime Gunbuster where they are trying to save the human race while traveling at light speed. They know if they engage the alien race they will never be able to see their friends or family again.
I think they ended up returning 12000 years later to find the entire planet waiting for them with a light display across the Earth that says "Welcome Home".
That text sent shivers down my spine. As for our mundane world: You usually can come back, but shit often gets in the way. I guess I'm getting kinda old-ish.
Not that long ago, people would migrate to another continent and literally never hear again about the people they left behind. I have a great grandfather that did that. It's really not that different from migrating to another star in that sense.