JSIL is also great, but its philosophy is that yo write .net code and run it in the browser, whereas Saltarelle's (and Script#'s) is that you write Javascript but with better tools. Also, the script that JSIL generates is very far from what you would write by hand, whereas that generated by Saltarelle/Script# can be distinguished from hand-written script primarily because the indentation is always correct and there is never an accidental loose comparison operator.
I think the tools fill different purposes, so integration with JSIL is absolutely a possibility in the future. I did not do any speed comparisons, I just translate what you write in C# to the equivalent script, so if you write a fast script it will be fast, if you write a slow script, it will be slow :)
Well, how you create data structures might matter for performance - if you turn C# structs into JS typed arrays for example and do the proper conversions, that could be much faster than simple JS objects or even arrays.