It does work really well and makes it really nice to walk or cycle inside your "zone" so to speak. The downside is that they concede the large avenues entirely to automobile centered design resulting in 10-13 way intersections that you have to navigate in order to get from one zone to another.

The most egregions example is probably the exit from Chapultepec leading into Condesa which drops you off next to a highway with no way of crossing without a 1KM detour:

https://www.google.com/maps/place/La+Condesa,+Mexico+City,+C...