I've noticed that many websites are just plain broken with Firefox, and I'm talking _big_ websites that don't even load because the JS doesn't work for some reason on Firefox, even with plugins disabled. Some of them are just functional on Webkit, makes me very sad for the future of the internet.
Not so long ago I'd have to check my front-end code for many different browsers, now it looks like some of them don't even bother with anything else than Chrome.
I've noticed that firefox always reports errors as "Script Error" and gives no stack trace, which makes it quite hard for me as a website maintainer to collect and fix browser specific errors. Chrome gives me nice, specific errors and stack traces so I can track down and fix the error quickly.