To me the most painful position by far is all fingers on home position.
If you ask a physical therapist what is the best way to sit on a chair they will say it is to switch position constantly. I'm not buying that it is opposite for a keyboard.
Moving around will help blood flow and will get you to release the static contraction (or switch muscles). That affects your forearm, wrists etc and I don't think has anything to do with your fingers.
For me, keeping at the home position limits wrist contortions that I associated with my increased pain.
This was the case for me as well, until I got myself a split ergo keyboard. With conventional keyboards, you have to twist your wrists for your fingers to stay on the home row (even more so if you have big hands).
If you ask a physical therapist what is the best way to sit on a chair they will say it is to switch position constantly. I'm not buying that it is opposite for a keyboard.