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Hm, no, non-24 is not just a severe version of DSPS. Or rather he seems to be saying DSPS is really just a less severe version of non-24.

I have it. What I've learned from my doc (a researcher in the field):

It's primarily a specific genetic mutation that affects many of they body's cyclic timers, but relevant here is that the circadian feedback loop is no longer able to lock to a 24 hour day/night cycle at all. The timer technically works. You're perfectly sensitive to light/dark, but you're hitting a PLL with inputs faster than its ability to make meaningful adjustments. That's not the case with DSPS.

Sleep apnea diagnosis is relevant here, it also breaks the breathing reflex timer. Imagine finding out at age 40 that you've not, in fact, slept more than a few minutes at a time your entire life, because you wake up just enough to take a breath every 3 minutes or so when a secondary suffocation reflex goes off.


It's more another example of 'you can sue for anything on a whim'.


What's the likelihood Dolby succeeds?


I'm still mostly without words; I just hear Ralph's voice in my head when I think about his passing. He was a force of warm, kind, friendly enthusiasm. We miss you, rillian.


"It's not a guidebook"...

This might be the scariest point. To me at least, it only felt obvious after stating it directly.


Q, more than any other glyph, is the letter that never fails to look weird in every typeface when I spend too much time looking at it/re-re-re-re-designing it.


He can, he did, and we're all here arguing about it, which somehow delights me.


Amazing what you can do when you throw 10 billion transistors at a problem instead of only a few million.


sort of like The Order of St. Liebowitz the Engineer from _A Canticle for Liebowitz_


Waiting for the Derek Lowe post, but... if this is legit, it's a 'holy flipping s**' moment. That kind of success in Phase I human trials is incredibly rare.


Had to look this up, seems like Derek Lowe is a reputable blogger[0] in this space

[0] https://www.science.org/blogs/pipeline


Look at the photos in the study that show the disappearing melanoma. Incredible.


This is actually some wonderful work that succinctly explains a lot of my experience. Much of how I was formally taught to program is counterproductive to the big picture the second someone else has to understand the code. It's part of the reason that I hate dealing with Rust and C++, and breathe a sigh of relief when the codebase I need to suck into my head is good old C. C offers fewer ways to hide all the working code in six layers of templates.


Nice to hear that it resonates with your experience. I liked C for the exact same reason. Switched to Golang recently, simplicity is cherished here too!


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