Yeah, I am considering purchasing ISRB "for research". Some people I love suffer with chronic inflammation due to various autoimmune diseases. I know plenty of amateur body builders buy chemicals "for research" but use them as supplements. They keep tabular and video artifacts like most body builders do, so I wonder to what degree the activities are illegal?
The problem with ISRIB is that it isn't water soluble. I'm not convinced that people who take it (usually subcutaneous injection or snorting it) aren't just experiencing placebo. I don't know of any way of actually getting the molecule to your body's cells in a consistent manner.
The study dissolved it in DMSO, then that in polysorbate 80, then that in polyethylene glycol. Then injected that intraperitoneally. That seems doable.
Intraperitoneal injection isn't really done in humans, the closest equivalent would be subcutaneous or maybe intramuscular injection. I don't know about the safety of injecting DMSO into humans but it's probably not too bad since it seems perfectly safe when used for transdermal drug delivery. The bigger problem is that you're injecting a water-insoluble compound mixed in a small amount of solvent into what is essentially a big bag of water. Once that DMSO/PEG/whatever is injected, it will just mix with the water in your body, so the ISRIB will just precipitate out of solution since it is now surrounded by 99% water molecules. So it will never get distributed to all your organs, which is the goal.
DMSO is soluble in both polar and non polar solvents. I assume the insolubility in water is precisely what they used it to solve.
Im any case, their delivery mechanism worked in mice, so it would work in people. The part that might not carry over to people is the effect once in the cell.
great article, having lived in New Mexico for many years I understand the passion of the people who looked for his treasure in the Rocky Mountains and especially the southern Rockies / Sangre de Cristo area...
This is one of the best pieces I have read on Forrest to date.
Just curious are you going to have a Github repo for applications that want to integrate with your product. Do you have any type of API that can talk to your app ? What programming language is your app written in and what front end framework are you using ?
Hi. I haven't really thought about open-sourcing the code and apps that might want to use SeeLink yet. However, I am working on an API since I'm building a Chrome extension to communicate with the product and make it easier to add links. Do you have any idea as to what kinds of apps might find communicating with SeeLink useful? The app is built in Python with Flask, and I have used Bootstrap on the frontend.
Well just to express my bias I am a big fan of open source and contribute to several open source projects; one of which I could see talking to your API if you had one. Also, not sure how many people have developed your application, but having lots of feedback from a community on discord or some such service; especially if in the future you decided to open source the project could solidify your project as the go to open source project in this space. I am not aware; but others could chime in current open source projects of this completeness like yours that are open source.
An example of an app that might want to integrate with your service could possibly be tools like https://www.notion.so
Agree with most of the points you have made here. Would be super cool if other open-source projects or applications could find a use for SeeLink. I haven't thought much about open sourcing the project yet, but I will definitely keep this option open in the future!
If you love the wilderness, love being out there in nature, this is as close as you can almost get in our modern world. I have an incredible respect for people who do these adventures and live to tell their stories...
and then tell them in a way that resonates with the way I would tell the story too...
More details in this article in Texas Monthly