I remember going to a LibrePlanet years ago (2012) and a woman gave an awesome presentation on the effort going into Gnome to make it more accessible. It also peaked my interest in Emacspeak.

One of the contributors to Emacspeak is also blind: T. V. Raman. He won an ACM distinguished doctoral dissertation award for his work:

https://en.wikipedia.org/wiki/T._V._Raman