It's absolutely must-try if you are the can't live without TabMixPlus type. Mission critical if you do any kind of ticket management/research at work. I frequently convert coworkers with the combo.
The development of nicotinic acetylcholine receptor agonists began in the early 1990s after the discovery of nicotine’s positive effects on animal memory.[2][3] The development of nicotinic acetylcholine receptor agonists has come a long way since then. The nicotinic acetylcholine receptor agonist are gaining increasing attention as drug candidates for multiple central nervous system disorders such as Alzheimer's disease, schizophrenia, attention-deficit hyperactivity disorder (ADHD) and nicotine addiction.[24][25]
<i>Interestingly enough, some pharmaceutical companies (like Targacept) have caught onto this phenomenon, and they have already started manufacturing nicotinic drugs (agonists of nicotinic receptors), which are to be marketed for the treatment of ADHD. They are trying to make nictoine more "safe"...
These so called nicotinic drugs, such as AZD3480 (Ispronicline), are still in the clinical trial phase. In fact, the drug is in phase trial II, which means that it has passed the so-called primary "safety test", and there were no alarming adverse reactions. See: http://clinicaltrials.gov/ct2/show/NCT00683462.
These nicotinic drugs are a refreshing new technology, because they indirectly act on dopamine through the release of another neurotransmitter, acetylcholine. These drugs are much unlike classic stimulants, which act upon the dopamine reward pathway directly, increasing abuse potential.
I decided to put the last question to the test. For the past week, I weaned myself of the Ritalin, and I bought transdermal nicotine patches. Bear in mind that I have never smoked a cigarette in my life, and none of my immediate family members smoke! So, what I did was highly risky as nicotine has been dubbed as a "highly addictive" drug.
...
On these so-called "dangerous" 5 mg patches, not only was I able to focus better and sleep better, but my mood was much more stable. Also, the "come-down" is nothing like that which I experienced with psychostimulants (more specifically, Ritalin). Now, I am not saying that we should all start smoking. But, I'm saying that we should keep an open mind and to keep our therapeutic options open.</i>
MAOIs are the last resort anti-depressants. There are two left on the US and they are extremely highly-regarded in effectiveness. They're more effective than the typical SSRIs of today but they are sadly not as prescribed today due to over-blown fears of interactions. It's a case of newer not always being better.
They work by preventing the breakdown of dopamine, serotonin, etc. therefore increasing levels in your brain.
In fact the gold standard for anti-anxiety is an MAOI, Nardil, which has additional inhibition leading to increased levels of GABA (the target of alcohol/benzodiazepines.)
In fact two medications in my daily mix with Nardil are on that list and it's such a pain dealing with ignorant pharmacists that see a warning on my their screen and refuse to call my doctor to confirm their combined safety, even though he's been practicing for 50 years (really.)
I urge you to read the various reports from real users confirming the safety even with the supposedly not safe to mix.
The problem is that most of the recommendations in the list were added before precise measuring of tyramine levels in foods was developed and list is one big CYA. To make matters worse is that nobody has made a significant effort to do real testing to define safe levels so most users are left to responsible trial and error.
I.E. read this about pepperoni, debunking the conventional "wisdom":
> BACKGROUND: Continuous refinement of the monoamine oxidase inhibitor (MAOI) diet has resulted in much reduced and simplified recommendations that attempt to balance safety and practicality. In the spirit of evidence-based practice, dietary restrictions should be based on carefully documented case reports and valid tyramine analyses. Residual concerns have focused on combination foods such as pizza and a variety of soy products. We determined the tyramine content of pizzas and a variety of soy products in order to refine dietary recommendations for use with MAOIs. METHOD: High-pressure liquid chromatography analysis of tyramine content was performed on a variety of pizzas, soy sauces, and other soybean products. A tyramine level of 6 mg or less was considered safe. RESULTS: No significant tyramine levels were found in any of the pizzas, including those with double pepperoni and double cheese. Marked variability was found in soy products, including clinically significant tyramine levels in tofu when stored for a week and high tyramine content in one of the soy sauces. CONCLUSION: Pizzas from large chain commercial outlets are safe for consumption with MAOIs. However, caution must be exercised if ordering pizzas from smaller outlets or gourmet pizzas known to contain aged cheeses. All soybean products should be avoided, especially soy sauce and tofu. Individualized counseling and continuous surveillance of compliance are still essential.
>
Bonus:
Tranylcypromine enhancement of nicotine self-administration.
Context Search (adds a context menu dropdown when you right click highlighted text; think plaintext words you search in trouble ticket type stuff) https://addons.mozilla.org/en-US/firefox/addon/context-searc...
Add To Search Bar (adds an option to search-engine-ify any submit text box) https://addons.mozilla.org/en-US/firefox/addon/add-to-search... (might as well mention https://addons.mozilla.org/en-US/firefox/addon/organize-sear...)
Bonus productivity favorite: https://addons.mozilla.org/en-US/firefox/addon/tree-style-ta...
So yeah, you'll pry Firefox away from my cold dead hands.