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The 1970s saw the birth of many foundational algorithms and concepts in machine learning, with research focusing on decision tree algorithms, clustering, and ensemble methods. I believe one of the first decision tree algorithms was created in 1973, crazy how early it all started!


In the 80's I apprenticed under a greybeard programmer who gave me all the shitty network code to write, while he experimented with neural networks instead of writing "old school" error correction logic for said network code.

I'm grateful for his bikeshedding, because it made me a network programmer and led to a fine career building Internet service providers, but I'll never forget his frustration .. "the computer is simply not big enough, we need to build a bigger computer" .. I wonder where he is these days. Hopefully retired.


Empathy plays a crucial role in strengthening human connections, which unfortunately I believe has been eroded strongly by social media and a rise in individualism. The combination of anonymity, and the modern day psychological wiring towards instant gratification, makes online cruelty largely rewarding unfortunately.


I mean it sounds great for materials extraction, but I’m a bit skeptical on infrastructure that will make long-term exploration and a lunar economy actually viable


What you are running into is most likely new user restrictions. Most subreddits have restrictions on posting and commenting based on account age, karma, or both


NO, it is some other issue. I have old account with high Karma.


God the way this was formatted is painful for the eyes, but TLDR the paper gives a pretty detailed overview of a method for mitigating the manipulation of URLs to artificially influence search rankings, which plagues many online service providers, especially in the retail and e-commerce sectors. Basically there’s a problem with editable URLs being exploited by automated systems or "click farms" to inflate the prominence of certain search results, which ultimately skews the integrity of web interactions and analytics. The paper does provide a solution to preserve the authenticity of user interactions and ensure that request data is verifiable, so if that’s your thing good luck trying to read this


This is such an incredible breakthrough and a huge win for science and families alike, however its sad that despite decades of work there is still no cure for mitochondrial disease. But the chance to preventing it being passed on is still such a major improvement. Also it’s sad that only the uk is capable of doing this atm bc it was the first country in the world to introduce laws to allow their creation after a vote in Parliament in 2015, while other countries were debating that it would open the doors to genetically-modified "designer" babies


The UK leads in this space as a previous PM had his newborn die of a genetic disease.

Amazing the domino effect.


David Cameron a conservative ex PM.

He's currently working in the genetic disease space: https://www.paediatrics.ox.ac.uk/news/former-uk-prime-minist...


It is an incredible breakthrough and if it prevents disease then all well and good, but are our Administrative Systems set up to handle such an arrangement?


Sure. The mitochondrial donor can be treated as a source of tissue and you are all done.


I really struggle why we keep maintaining some archaic definitions around the “family unit” anyway. So someone has 3 parents instead of 2 - nothing wrong with that.


It's ok to not know why something is.

My daughter doesn't know why we have archaic laws around seatbelts either, but she's 3.


This makes no sense.

The seatbelt laws are not archaic by any meaning of the word, and they can be justified with rational arguments.

Care to try doing the same for family thing? Aside from tradition.


It's not that hard to imagine a rational argument where humans have evolved to grow with one or two parents, leading to all sorts of psychological prewiring.

(I'm not supporting the argument, just saying that it's not hard to come up with a plausible rational one)


> not that hard to imagine a rational argument where humans have evolved to grow with one or two parents

The modern nuclear family is, well, modern. Children were collectively raised in most cultures. (Certainly almost all that gained prominence.)


To what extent? for example, imagine they still had identifiable parents with some some prominent role. I could also see the argument that parental role is diminished in modern society with the outsourcing to public schools.

(genuine questions)


> To what extent?

The earliest evidence for nuclear families is in Germany, going back 3,000+ BCE [1]. We next seem it gain prominence in 13th-century England [2]. Otherwise, the default for non-nomadic societies was kin (extended family) or community oriented childrearing. Similar to what we see in traditional family structures in South America, Southern Europe and Asia.

> could also see the argument that parental role is diminished in modern society with the outsourcing to public schools

It would be difficult to make this argument given the primacy of parents in public schooling compared with e.g. their diminished role in kin- or community-based childrearing systems.

[1] https://www.sciencedaily.com/releases/2008/11/081117192915.h...

[1] https://www.taylorfrancis.com/chapters/mono/10.4324/97813151...


Before DNA testing nobody could tell anyway.


Cells can exchange mitochondria so in theory it might be possible to flood the body with healthy mitochondria and get them to slowly take over.


I would expect that to activate the immune system. "the unique components of mitochondria, when exposed, reveal their prokaryotic history and are recognized as foreign by innate immune receptors triggering an inflammatory response." https://pmc.ncbi.nlm.nih.gov/articles/PMC6218307/

Maybe if you suppress the immune system, introduce working mitochondria, and then stop taking the immunosuppressants, any mitochondria that are still outside cells get cleaned up and the ones that got absorbed are shielded and can do their job.


Maybe we can find some way to deliver mitochondria right into the cells.


Mitochondrial health is definitely going to be a big theme in the coming years.


> it might be possible to flood the body with healthy mitochondria and get them to slowly take over

it's not possible, these are organelles that are too big to be taken up by your cells, unless you can magically teleport them somehow to each cell


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